photos from yesterday

On the CYPs/Sips

Finished exams on tuesday with toxicology. Yesterday was spent hungover and in bed. An expected outcome? probably. But the result of 5 or 6 weeks without drinking a beer I believe resulted in a downregulation of the CYP2E1 and Alcohol dehydrogenase enzymes in my liver hepatocytes. The result being a large accumulation of aldehydes and the symptoms of tachycardia, NVD (nausea vomitting and diarhoea) facial flushing and headache. Alcohol is an extensive CYP2E1 inducer, the combination of a big night and a CYP3A inducer like ketoconazole (antifungal) and widely used headache cure like paracetamol is likely to cause a huge increase in flux of paracetamol in the to the harmful metabolite NAPQI, this accumulation is likely to saturate the only safe detoxification pathway (GSH/GST), bind to nucleic acids of hepatocyte DNA and cause cell necrosis. fortunately i didn't take any paracetamol, was left with a headache and now deal with the consequences of fatty liver, a temporary fat accumulation in hepatocytes which rarely results in cell death.

Just mucking round with the exposure on my new comp. Awaiting freedom from Pharmacology, toxicology and Law on tuesday with my last exam

My best impression of Augustino Clark

executive decision, the blog wasn't reaching the target audience, decided to change my target audience..... fim da historia, fica bem mulhekes, sangue bom....

.....

Thought about the lack of activity and probably therefore relevance of this site. Some might say it's shit and at times they were probably right. But then again creativity is often a difficult emotion to express when your spirit is stuck in a lifestyle of stagnation. Spending the past 8 weeks studying for exams which as it happens are next week tends to put things a little in perspective. Is it actually really worth it. I mean working this hard for something your not totally sure you actually want. Just giving yourself another option..... Well you'd be stupid not to question the validity of the exercise, wouldn't you?