On the CYPs/Sips

Finished exams on tuesday with toxicology. Yesterday was spent hungover and in bed. An expected outcome? probably. But the result of 5 or 6 weeks without drinking a beer I believe resulted in a downregulation of the CYP2E1 and Alcohol dehydrogenase enzymes in my liver hepatocytes. The result being a large accumulation of aldehydes and the symptoms of tachycardia, NVD (nausea vomitting and diarhoea) facial flushing and headache. Alcohol is an extensive CYP2E1 inducer, the combination of a big night and a CYP3A inducer like ketoconazole (antifungal) and widely used headache cure like paracetamol is likely to cause a huge increase in flux of paracetamol in the to the harmful metabolite NAPQI, this accumulation is likely to saturate the only safe detoxification pathway (GSH/GST), bind to nucleic acids of hepatocyte DNA and cause cell necrosis. fortunately i didn't take any paracetamol, was left with a headache and now deal with the consequences of fatty liver, a temporary fat accumulation in hepatocytes which rarely results in cell death.